Sunday, December 27, 2020

No need for ICU beds with US practice near US-Mexico border. “Slowing the spread” is fringe benefit when primary purpose is saving lives with published early treatment-Desert Review, Imperial Valley, Calif.

 .

Includes follow up to Dr. Fareed’s Nov. 19, 2020 U.S. Senate hearing, “Early Outpatient Treatment: An Essential Part of a Covid-19 Solution:”

12/12/20, “Dr. George Fareed and Dr. Brian Tyson share early treatment protocol,” The Desert Review, Brawley, Imperial Valley, Calif.

“Dr. George Fareed, Imperial Valley [Calif.] frontline doctor fighting against the COVID-19 pandemic locally, has been fielding phone calls from across the nation helping those afflicted but unable to get early treatment from their medical establishments.

“I’m really busy, but I’m willing to help anyone,” Fareed said.

The doctor reached out to The Desert Review suggesting publication of the Protocol he and Dr. Brian Tyson have refined for their local patients that has been so successful. Fareed also included in his material what Dr. Zelenko, a pioneer in repurposing medicines for the virus has developed as a prophylaxis, a preventative subscription [which is mainly zinc, Vitamin C, and Quercetin, posted below]….

[10/19/20, Dr. Brian Tyson reported 100% success rate treating Covid early.“We were at the heart of the pandemic due to our large Hispanic and diabetic population.” Dr. Tyson said Imperial Valley shares an international border in the south with Mexicali, Mexico which has a population of 1.5 million residents. He treated 1,900 positive patients….“We treated this virus early….We only had one hospitalization and zero deaths. Zero deaths, because we were not going to stand by and allow people to die without treatment,” Dr. Tyson said.” 10/19/20]

(continuing): “Also included in the material submitted, is a follow up to Dr. Fareed’s U.S. Senate hearing, “Early Outpatient Treatment: An Essential Part of a COVID-19 Solution” held November 19 in the Capitol.

Senator Josh Hawley submitted questions to Dr. Fareed to clarify his testimony for the record. Here is the correspondence between the Senator and Fareed on December 10:

Sen. Hawley: In your testimony, you say that timing is everything when it comes to treatment and that the best time for outpatient treatment to prevent hospitalization comes when “the virus is in a period of maximum replication in the upper respiratory tract.” Can you explain what this would mean for a patient? Would this be five days after exposure, or ten days? Or is it based on symptoms?  

Dr. Fareed: The earlier the treatment can be started after the start of the infection, the better and more rapid the recovery (as well as the reduction in the risk of spread/contagious period). This would mean that the patient should optimally start the treatment in the first 4 days of the infection and within five days of exposure. It usually is based on symptoms which start within 1-4 days of viral entry into the upper respiratory system. Even starting the multi-faceted treatment later (7-10 days after infection) is also very worthwhile if severe pneumonia necessitating hospitalization has not yet set in.

Sen. Hawley: In your experience, are patients typically coming in to get treated at this point in their illness? And if not, what do you think we need to do to encourage high-risk individuals to to seek outpatient treatment and care? 

Dr. Fareed: More patients are coming in to get treated or contacting me from afar for treatment when they can’t receive the treatment in their local communities. Sadly, many infected people and primary care doctors and doctors in ERs follow the NIH and Dr. Fauci stipulations with no effective treatments offered. We need to have the NIH/FDA/CDC formally acknowledge the importance of early treatment with moderately acting, safe anti-virals so readily available. When (if ever) that happens, everything would improve dramatically. Thank you, Senator Hawley, for all your efforts and for allowing me to respond to these excellent questions.

The following is the protocol Drs. Fareed and Tyson have jointly developed as most effective for their COVID-19 patients:

Fareed/Tyson COVID-19 Treatment Protocol

HCQ 200 mg tabs [pills] #16 (HCQ = hydroxychloroquine) [HCQ was approved by FDA in 1955 and had been used in hundreds of millions of prescriptions worldwide since then. (scroll down)]

Zinc sulfate 22O mg (or elemental Zinc 50 mg) # 15

Azithromycin 500 mg # 5 (or Z pack) or

Doxycycline 100 mg # 10)

Ivermectin 3 mg tabs #8

Aspirin 325 mg tabs #30

Day 1 – HCQ 2 tabs twice a day

Zinc sulfate tab twice a day

(Azithromycin tab one per day or doxycycline cap twice a day)

Ivermectin 12 mg on day 1 only

Aspirin 325 mg

Days 2-5 

HCQ tab 3 times a day

Zinc sulfate 3 times a day

(Azithromycin tab daily or doxycycline cap twice a day)

Aspirin 325 mg daily

Ivermectin 12 mg on day 3 if symptoms warrant

Prednisone 60 mg daily x 5-7 days or

Dexamethasone 4 mg bid if wheezing /SOB

Budesonide 0.5-1mg/2ml vía nebulizer bid

Vitamin D3 5000 iu daily

Pepcid 20 mg daily

Continue daily Aspirin 325 mg

Over the counter prevention:

Elemental Zinc 25 mg once a day

Vitamin D 4000 iu once a day

Vitamin C 1000 mg once a day

Quercetin 500 mg once a day

If Quercetin is unavailable, then use Epigallocatechin-gallate (EGCG) 400mg once a day

Dr. Fareed also included Dr. Zelenko’s (Twitter: @zev_dr [Here’s an alternate source for Dr. Zelenko’s work. On Dec. 23 twitter suspended Dr. Zelenko’s account.…Another helpful twitter site: https://twitter.com/CovidAnalysis]) COVID-19 Prophylaxis Protocol: 

Prophylaxis is an action taken to prevent or protect against a specified disease. Greek in origin, from the word “phylax”, meaning “to guard” and “watching.”

Low Risk Patients

Young healthy people do not need prophylaxis against COVID-19. In young and healthy people, this infection causes mild cold-like symptoms. It is advantageous for these patients to be exposed to COVID-19, build up their antibodies and have their immune system clear the virus. This will facilitate the development of herd immunity and help prevent future COVID-19 pandemics. However, if these patients desire prophylaxis against COVID-19, then they should take the protocol noted below.

Moderate-Risk Patients

Patients from this category are healthy but have high potential viral-load exposure. This group includes medical personnel, caregivers of high-risk patients, people who use public transportation, first responders and other essential personnel who are crucial to the continued functioning of society. These patients should be encouraged to take prophylaxis against COVID-19 in accordance with the protocol noted below.

High-Risk Patients

Patients are considered high risk if they are over the age of 60, or if they are younger than 60 but they have comorbidities, that is, they have other health conditions that put them at risk. These patients have between a 5 to 10 percent mortality rate if they are infected with COVID-19. These patients should be strongly encouraged to take prophylaxis against COVID-19 in accordance with the protocol noted below. 

Protocol for Low and Moderate Risk Patients:

Elemental Zinc 25 mg once a day[1]

Vitamin C 1000 mg once a day[2]

Quercetin 500 mg once a day

If Quercetin is unavailable, then use Epigallocatechin-gallate (EGCG) 400 mg once a day[3]

Protocol for High-Risk Patients:

Elemental Zinc 25 mg once a day

Hydroxychloroquine (HCQ[4]) 200 mg once a day for five days, then once a week

If HCQ is unavailable, then use the Protocol for Low and Moderate Risk Patients.”

[1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365891/

[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318306/

[3]https://pubs.acs.org/doi/10.1021/jf5014633

[4]https://www.preprints.org/manuscript/202007.0025/v1

…………………………………….

Additional source, early outpatient treatment:

May 27, 2020, Early Outpatient Treatment of Symptomatic, High-Risk COVID-19 Patients That Should Be Ramped Up Immediately as Key to the Pandemic Crisis,Dr. Harvey A. Risch, American Journal of Epidemiology

…………………………………………..

Added: Dramatically lower death rates in countries allowing early HCQ protocol and widespread prophylactic use:

May 29, 2020, “Break the FDA Barriers! Make Hydroxychloroquine Over-The-Counter,” Elizabeth Lee Vliet, MD, Preventive Medicine

A study by Dr. Harvey A. Risch, professor at Yale’s School of Public Health, “of hydroxychloroquine plus azithromycin in more than 300,000 older adults, just published May 27, 2020 said: “Evidence about use of hydroxychloroquine alone, or of hydroxychloroquine+azithromycin in inpatients, is irrelevant concerning efficacy of the pair in early high-risk outpatient disease. Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacyThese medications need to be widely available and promoted immediately for physicians.

Early treatment with HCQ, and widespread prophylactic use, are the critical factors that led to the dramatically lower death rates in countries such as India (2/million), Australia (4/million), South Korea (5/million), Argentina (8/million) as of May 18.

By delaying HCQ use until people are already critically ill in the hospital, the US now has a markedly higher death rate from COVID-19 (278/one million population as of May 18), even though we had adequate hospital beds, ventilators and other equipment. Data by countries on May 18, 2020, which is updated daily, shows the stunning differences:

[Ed. note: I couldn’t find above chart or any mention of HCQ at the Worldometers link provided. The author may have used Worldometers numbers and added HCQ policy from other sources.]

………………………………………….

Added: HCQ protocol status by country:

11/14/20,Early treatment with hydroxychloroquine: a country-based analysis,hcqtrial.com…Twitter site, Covid Analysis

“Covid Analysis, August 5, 2020 (Version 35, November 14, 2020)“…[Covid Analysis twitter site]

…..
We are PhD researchers, scientists, people who hope to make a contribution, even if it is only very minor. You can find our research in journals like Science and Nature. For examples of why we can’t be more specific search for “raoult death threats” or “simone gold fired”. We have little interest in adding to our publication lists, being in the news, or being on TV (we have done all of these things before but feel there are more important things in life now). 
 
 
There is no need to. We provide organization and analysis, but all sources are public and you can easily verify everything. For the country-based analysis, all data is public and the analysis is simple to replicate. We also note that many equally qualified experts report contradictory conclusions. If you don’t like our analysis, you can use our database to locate information you may have missed for your own research. 
 
 
We have no funding, this is done in our spare time and we pay the web hosting fees personally (about $100 per month).”
 
 “Results  
 

Appendix 13. Country HCQ Status…

These countries were excluded because they have no or very little spread to date. They may be included in the future if they experience significant spread. 
 
Algeria widespread early treatment for high-risk patients for most of the outbreak. Adopted HCQ in early April and continued to use after WHO warning.
The Africa Report, https://www.theafricareport.c..ne-from-dakar-to-brazzaville/, Coronavirus: Didier Raoult the African and chloroquine, from Dakar to Brazzaville, 4/15.
Afrik.com, https://www.afrik.com/edouard..ychloroquine-et-le-remdesivir, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, Follows the Raoult protocol, 7/6.
The East African, https://www.theeastafrican.co..902-5564930-duphp6/index.html, Algeria backs use of malaria drug despite WHO dropping trials, 5/27.
Al-bab, https://al-bab.com/blog/2020/..-chloroquine-despite-concerns, Covid-19: Algeria and Morocco continue using chloroquine despite concerns, 5/28.
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Parola et al., https://www.mediterranee-infe..2020/09/COVIDAfricaJOUMII.pdf, COVID-19 in Africa: What else?, letter regarding the large use of CQ derivatives and the relative success of countries using them, 9/11.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1258469706442444804, Algeria’s Health Minister praises HCQ used since the end of March, 5/7.
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
Bahrain – widespread early treatment (excluded due to young population)
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1260588201179144193, Adopted as standard treatment very early, 5/13.
Al Arabia, https://english.alarabiya.net..oroquine-to-treat-coronavirus, Bahrain among first countries to use Hydroxychloroquine to treat coronavirus, Used since the first case, 3/26.
GulfInsider, https://www.gulf-insider.com/..-medication-proved-effective/, Coronavirus: Bahrain’s Therapeutic Medication Proved Effective, Effectiveness of HCQ confirmed, 5/25.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, use not suspended post WHO/Lancet, 6/1.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Used early, 5/2.
Belarus – mixed use of early treatment with HCQ
Belarus Ministry of Health, https://twitter.com/NNeanderM..al/status/1269683561147305985, Use of hydroxychloroquine (HCQ) in Belarus, 6/7.
Jared Young, https://twitter.com/jtyoung18/status/1258279092010586113, In inpatient and outpatient protocols, 5/6.
BelTA, https://eng.belta.by/society/..vid-19-treatment-130102-2020/, Belarus to receive potential effective drug for COVID-19 treatment, 4/29.
BelTA, https://eng.belta.by/society/..ide-of-hospitals-130777-2020/, Belarus suspends use of chloroquine for COVID-19 outside of hospitals, 6/2.
Brazilearly HCQ treatment was adopted relatively late
Late and very mixed use, increasing over time.
Brazilian Society of Pulmonology and Tisiology, https://sbpt.org.br/portal/t/cloroquina/, Declaração da SBPT sobre o tratamento da COVID-19, recommending against using CQ/HCQ, 7/22.
Filipe Rafaeli, https://medium.com/@filiperaf..nt-human-history-2685487ad717, Hydroxychloroquine: the narrative that it doesn’t work is the biggest hoax in recent human history, almost unanimity of Brazilian scientists are against the application of these drugs and repeat that “there is no scientific evidence” of the functioning, 7/23.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1273878906785972224, Clinical outcomes improve after adoption of HCQ starts, 6/19.
CNN, https://www.cnnbrasil.com.br/..-para-casos-leves-de-covid-19, Government changes protocol and authorizes hydroxychloroquine for mild cases of Covid-19, 5/20.
Último Segundo, https://ultimosegundo.ig.com…tao-zerados-diz-pazuello.html, Estoques de hidroxicloroquina no país estão zerados, diz Pazuello, government has run out of HCQ. Distribution data indicates only a small portion of cases receive HCQ, 8/13.
The Verge, https://www.theverge.com/2020..navirus-jair-bolsonaro-maduro, Twitter removes tweets by Brazil, Venezuela presidents for violating COVID-19 content rules, 3/30.
Agência Brasil, https://agenciabrasil.ebc.com..dicoes-para-uso-da-cloroquina, CFM estabelece critérios e condições para uso da cloroquina, there is no “solid evidence” to confirm the effect of CQ and HCQ, 4/23.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1279445536685383680, One by one municipalities are adopting HCQ, 7/4.
Diário de Uberlândia, https://diariodeuberlandia.co..tada-a-pacientes-com-covid-19, Farmacêuticos não podem negar venda de cloroquina receitada a pacientes com Covid-19, high degree of controversy in Brazil, 7/3.
Burkina Faso – widespread early treatment (excluded due to young population)
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
LifeSiteNews, https://www.lifesitenews.com/..loss-of-life-from-covid-virus, Doctors insist this cheap, safe drug is “key to preventing huge loss of life” from Wuhan virus, widely used, 6/5.
The Africa Report, https://www.theafricareport.c..ne-from-dakar-to-brazzaville/, Coronavirus: Didier Raoult the African and chloroquine, from Dakar to Brazzaville, 4/15.
Cameroon – widespread early treatment (excluded due to young population)
France 24, https://www.france24.com/en/2..expert-becomes-state-protocol, Covid-19: In Cameroon, chloroquine therapy hailed by French expert becomes state protocol, 5/3.
Voice of America, https://www.voanews.com/scien..-scale-chloroquine-production, Cameroon Begins Large-scale Chloroquine Production, 4/13.
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
France 24, https://www.france24.com/fr/2..%A9e-en-protocole-d-%C3%A9tat, Covid-19 : au Cameroun, la méthode Raoult érigée en protocole d’État, adopted the Raoult protocol, 5/2.
.......
Canada limited early treatment with HCQ
Physicians not allowed to use. New Brunswick used briefly until stopped by Health Canada.
Maclean’s, https://www.macleans.ca/socie..e-rise-of-hydroxychloroquine/, The incalculable rise of hydroxychloroquine, Health Canada has not permitted physicians to administer HCQ for COVID, 5/21.
CBC, https://www.cbc.ca/news/healt..-experimental-drugs-1.5511244, Doctors face sanctions for prescribing [allegedly] unproven COVID-19 drugs to friends and family, regulators warn, except when there is a clinical trial, the statement instructs both doctors and pharmacists not to provide the drugs as a treatment for COVID-19, 3/27.
Acadie Nouvelle, https://www.acadienouvelle.co..e-la-covid-19-deploye-au-n-b/, EXCLUSIF: un traitement expérimental contre la COVID-19 déployé au N.-B., New Brunswick adopts HCQ, 4/2.
Acadie Nouvelle, https://www.acadienouvelle.co..-experimental-de-la-covid-19/, Le Nouveau-Brunswick fait marche arrière sur le traitement expérimental de la COVID-19, Health Canada ended New Brunswick’s use of HCQ on 4/17, 5/10.
CBC, https://www.cbc.ca/news/canad..ur-gill-tweets-cpso-1.5680122, Ontario doctor subject of complaints after COVID-19 tweets, HCQ has been shown to be ineffective. Medical bodies such as the Canadian Pediatric Society say HCQ has no significant benefit in fighting COVID-19. Health Canada has not authorized HCQ to treat or cure COVID-19. It says HCQ can have serious side effects, 8/10.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1256869896014704640, New Brunswick broke ranks with Canada adopting HCQ, 5/3.
ChloroquineGorilla, https://twitter.com/Prolongin..id/status/1277927519203635205, Quebec has some of the harshest anti-HCQ rules in the world, 6/30.
Chad – widespread early treatment (excluded due to young population)
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
Chile mixed use of early treatment with HCQ
Cristian Navarro Merino, https://twitter.com/cnnavarro1/status/1272207814749020160, Stopping because of WHO/Lancet, 6/14.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1265400801507315712, Chile stops HCQ, 5/26.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, banned, 6/1.
Veronica Riveros, https://twitter.com/veronicar..oc/status/1270558291714867200, People fear HCQ, 6/9.
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Costa Rica widespread early treatment for high-risk patients for most of the outbreak. Used early based on recommendation from China 3/18.
The Tico Times, https://ticotimes.net/2020/06..nue-partnership-with-coursera, News briefs: Reopening plans on-track, hydroxychloroquine use to continue, partnership with Coursera, HCQ use continuing after FDA revoked EUA, 6/15.
Q Costa Rica, https://qcostarica.com/hydrox..ccessfully-to-fight-covid-19/, Hydroxychloroquine: The Drug Costa Rica Uses Successfully To Fight Covid-19, 4/19.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Used early, 5/2.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1264837406802444288, First and only Central American country to immediately adopt, 5/25.
J David, https://twitter.com/badlandj/status/1267509994368503814, Costa Rica refuses WHO recommendation to stop using HCQ, 6/1.
............
Cubawidespread early treatment for high-risk patients for most of the outbreak. Using to treat at an early stage.
Pleno.News, https://pleno.news/saude/coro..id-com-hidroxicloroquina.html, Cuba stands out in combating Covid with hydroxychloroquine, using low doses of HCQ to treat Covid-19 at an early stage, 7/12.
Anadolu Agency, https://www.aa.com.tr/en/amer..tent-against-covid-19/1905650, Cuba: Early hydroxychloroquine potent against COVID-19, “We are aware of the polemics around this product. Physicians here mostly have a good opinion of the results it has achieved, provided that it is used at an early stage in low doses and only with patients without comorbidities, which could be complicated by hydroxychloroquine”, 7/10.
Czech Republic – widespread early treatment (excluded due to early isolation)
Supported use since early March.
Expats.cz, https://news.expats.cz/weekly..-hospitals-to-treat-covid-19/, Czech Health Ministry permits temporary use of hydroxychloroquine to treat COVID-19, temporary permit for 8 months, 4/7.
Ministerstva Zdravotnictví, https://www.mzcr.cz/rozhodnut..ychloroquine-sulfate-tablets/, Rozhodnutí o dočasném povolení neregistrovaného humánního léčivého přípravku HYDROXYCHLOROQUINE SULFATE TABLETS, authorization of HCQ, 4/30.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1257696987576557568, Support for HCQ in early March, 5/4.
Djibouti widespread early treatment (excluded due to small population)
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
Global Times, https://www.globaltimes.cn/content/1189839.shtml, Chinese medical expert decorated by Djibouti for COVID-19 prevention, 5/28.
Face 2 Face Africa, https://face2faceafrica.com/a..spite-big-covid-19-recoveries, Djibouti, others warned about chloroquine despite big COVID-19 recoveries, 5/23.
VOA, https://www.voanews.com/covid..ce=dlvr.it&utm_medium=twitter, Djibouti is Treating All COVID Patients with Chloroquine, But Scientists Urge Caution, 5/21.
...........
Francelimited early treatment with HCQ
Banned post WHO/Lancet. Used late stage in hospitals. Limited early treatment, some exceptions, especially in Marseille. Media very negative.
Reuters, https://www.reuters.com/artic..fety-fears-grow-idUSKBN2340A6, EU governments ban malaria drug for COVID-19, trial paused as safety fears grow, banned May 27, previously generally only in hospitals, 5/27.
Afrik.com, https://www.afrik.com/edouard..ychloroquine-et-le-remdesivir, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, HCQ prohibited outside hospitals, 7/6.
CBS News, https://www.cbsnews.com/news/..NM-00-10aab7e&linkId=89534081, France bans use of hydroxychloroquine, drug touted by Trump, in coronavirus patients, 5/27.
The New York Times, https://www.nytimes.com/2020/…html?searchResultPosition=17, France Bans Malaria Drug for Coronavirus Treatments, 5/27.
................
Germany – mixed use of early treatment with HCQ
We found several reports of early treatment early in the outbreak, confirmed by Sermo, later reports of trials paused post WHO/Lancet, current status of early treatment is unclear.
Andreas Backhaus, https://twitter.com/AndreasSh..ed/status/1295790850790895621, Off-label prescriptions were banned between early April and early July, 8/18.
Mediapart, https://blogs.mediapart.fr/br..t-utilise-lhydroxychloroquine, L’Allemagne a massivement utilisé l’hydroxychloroquine!, Germany has massively used HCQ, 10/21.
Col Pavan Nair, https://twitter.com/pavannair/status/1289884254365655043, Used early in the outbreak, 8/2.
RP Online, https://rp-online.de/wirtscha..d-malaria-mittel_aid-50034873, Bayer spendet acht Millionen Chloroquin-Tabletten, donation of 8 million CQ tablets, 4/14.
DAZ.online, https://www.deutsche-apotheke..dnungen-von-hydroxychloroquin, BfArM: Keine ambulanten Off-Label-Verordnungen von Hydroxychloroquin, 6/4.
pressenza, https://www.pressenza.com/fr/..-voie-du-movimento-ippocrate/, Vaincre la peur : la voie du “Movimento Ippocrate”, “in Germany, the extensive use of HCQ, AZ, and a large amount of hyperimmune plasma has kept the death rate below 3%. But in great silence, as the Germans know how to do”, 7/10.
Andreas Backhaus, https://twitter.com/AndreasSh..ed/status/1295752761095618569, Federal institute for disease control and prevention advises against the use of HCQ, 8/18.
Munchensenton, https://twitter.com/Munchensenton/status/1286659832741867520, Started using early, 7/24.
Christopher Kidwell, https://twitter.com/Lerianis1/status/1288039709218922496, Early treatment used, 7/28.
Reuters, https://www.reuters.com/artic..ovid-19-spiegel-idUSKBN2343AL, Germany pauses anti-malaria drug study for COVID-19: Spiegel, two week pause in trial, 5/28.
Ghana – widespread early treatment (excluded due to young population)
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
AfricaFeeds, https://africafeeds.com/2020/..e-to-treat-covid-19-patients/, Kenya approve the use of Chloroquine to treat COVID-19 patients, 4/1.
Pan African Medical Journal, https://www.panafrican-med-jo..m/content/series/37/1/9/full/, Clinical characteristics, treatment regimen and duration of hospitalization among COVID-19 patients in Ghana: a retrospective cohort study, research paper noting that the results support the Ghana standard treatment guidelines that if not contraindicated, HCQ or CQ should be used alone or in combination with AZ, 9/15.
The Guardian, https://guardian.ng/news/nige..id-19-prevention-says-nafdac/, Chloroquine potent for COVID-19 prevention, says NAFDAC, 8/26.
Greecewidespread early treatment for high-risk patients for most of the outbreak
Medical Xpress, https://medicalxpress.com/new..versy-greece-chloroquine.html, Amid global controversy, Greece moves forward with chloroquine, greek epidemiologists consider chloroquine effective, especially in the early stages of COVID-19, 6/10.
Barron’s, https://www.barrons.com/news/..-with-chloroquine-01591781707, Amid Global Controversy, Greece Moves Forward With Chloroquine, the ongoing debate over the drugs has had little impact in Greece, where epidemiologists consider chloroquine effective, especially in the early stages of COVID-19, 6/10.
Afrik.com, https://www.afrik.com/edouard..ychloroquine-et-le-remdesivir, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, Follows the Raoult protocol, 7/6.
Guinea – widespread early treatment (excluded due to young population)
Mosaique Guinee, https://mosaiqueguinee.com/tr..vec-lhydroxychloroquine-anss/, Traitement des malades de covid19 en Guinée: « nous continuons avec l’hydroxychloroquine » (ANSS), ignoring WHO recommendation, 5/25.
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Indiawidespread early treatment for high-risk patients for most of the outbreak
Rathi et al. Lancet Infect. Dis. doi:10.1016/S1473-3099(20)30313-3, https://www.thelancet.com/jou..1473-3099(20)30313-3/fulltext, Hydroxychloroquine prophylaxis for COVID-19 contacts in India, ICMR recommends chemoprophylaxis with HCQ for asymptomatic health-care workers and asymptomatic household contacts of confirmed cases, 4/17.
Atikh Rashid, https://indianexpress.com/art..te/?__twitter_impression=true, Maharashtra expands use of hydroxychloroquine as preventive measure, 4/23.
Ministry of Health and Family Welfare, https://twitter.com/Billtheicon/status/1262508966321496066, Advised all front line health care workers to take HCQ prophylactically, 3/28.
Oneindia, https://www.oneindia.com/indi..-health-ministry-3111048.html, No COVID-19 death in Manipur, Mizoram, Nagaland, Sikkim so far: Govt, HCQ widely distributed, 6/26.
Dr. Goldin, https://www.facebook.com/grou..e/permalink/2367454293560817/, Summary of HCQ usage in India from an MD in India, everyone diagnosed with COVID-19 gets HCQ, it is the standard of care country-wide. The only problem is some patients come very late, deaths are from those who wait too long before seeking medical help. Everyone at high risk, including policemen, firemen, healthcare workers, and nursing home patients, take HCQ, all contacts of positive cases also get HCQ prophylaxis. HCQ is OTC in India, so everyone else is also welcome to use it, 8/21.
AFP, https://www.msn.com/en-ph/new..evention/ar-BB14EloP?ocid=st2, India backs hydroxychloroquine for virus prevention, 5/27.
AAPS, https://aapsonline.org/hcq-90-percent-chance/, Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients, many nations, including Turkey and India, are protecting medical workers and contacts of infected persons prophylactically, 4/28.
The Indian Express, https://indianexpress.com/art..s-as-analysis-begins-6486049/, Vadodara administration drive: HCQ helping in containing Covid-19 cases, say docs as analysis begins, used prophylactically in Vadora with positive results, 7/2.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, used as preventative measure, 6/1.
Government of India, https://www.mohfw.gov.in/pdf/..edHomeIsolationGuidelines.pdf, The caregiver and all close contacts of such cases should take HCQ prophylaxis, 7/2.
The Australian, https://www.theaustralian.com..56d1371697fe69e4fcc39d7f1f97c, India and Indonesia stand by antimalarials, 5/29.
Indonesia – widespread early treatment (excluded due to early isolation)
Reuters, https://www.reuters.com/artic..o-stop-using-it-idUSKBN23227L, Exclusive: Indonesia, major advocate of hydroxychloroquine, told by WHO to stop using it, Indonesia told doctors to use HCQ to treat all COVID-19 patients with symptoms from mild to severe, 5/26.
The Australian, https://www.theaustralian.com..56d1371697fe69e4fcc39d7f1f97c, India and Indonesia stand by antimalarials, 5/29.
Sag Leyos, https://twitter.com/sagleyos/status/1274992969549037569, Treatment given early, do not need to wait for test results, 6/22.
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Ireland – limited early treatment with HCQ
Robert Nugent, https://twitter.com/RobertANu..t1/status/1268877953825419264, Nobody treated early with HCQ in Italy, 6/5.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1255194379255504897, Ireland waits for clinical trials, 4/28.
Israel mixed use of early treatment with HCQ
We initially believed that Israel had widespread early use for the majority of the outbreak, but we received reports that Israel’s use for early treatment has not be as widespread as believed.
The Times of Israel, https://www.timesofisrael.com..fit-in-virus-treatment-study/, Malaria drug stockpiled by Israel shows no benefit in virus treatment — study, no official guidance but doctors can prescribe, 4/22.
Anatoly Lubarsky, https://twitter.com/anatoly/status/1295791524131766273, Prescriptions of HCQ off-label was banned in late March, 8/18.
Judy Breton, https://twitter.com/JudyBreton/status/1293768018087104513, Israeli Ministry of Health has forbidden doctors from writing scripts for HCQ for COVID-19, 8/12.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1256949969036214275, Received 2 million doses from Teva mid April, 5/3.
Haaretz, https://www.haaretz.com/israe..o-treat-coronavirus-1.8712940, Israel Preparing to Use Unapproved Medication to Treat Coronavirus, preparing to use HCQ, 3/26.
AAPS, https://www.prnewswire.com/ne..-surgeons-aaps-301098030.html, More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by the AAPS, greater access to HCQ, 7/22.
Xinhua, http://www.xinhuanet.com/english/2020-04/09/c_138961933.htm, Israel brings anti-malarial drug from India to fight COVID-19, 4/9.
Italy – early HCQ treatment was adopted relatively late
Banned post WHO/Lancet. Some early treatment started late in Italy’s outbreak.
Reuters, https://www.reuters.com/artic..fety-fears-grow-idUSKBN2340A6, EU governments ban malaria drug for COVID-19, trial paused as safety fears grow, banned May 27, 5/27.
Talking Points Memo, https://talkingpointsmemo.com..the-use-of-hydroxychloroquine, Italian Pharmacological Agency Warns Against The Use Of Hydroxychloroquine, 5/22.
Trustnodes, https://www.trustnodes.com/20..tment-with-hydroxychloroquine, Italy Finally Starts Mass Treatment with Hydroxychloroquine, early treatment starts in some areas, 3/29.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, banned except clinical trials, 6/1.
CBC, https://www.cbc.ca/news/world..9-over-safety-fears-1.5586220, France, Italy, Belgium act to stop use of hydroxychloroquine for COVID-19 over safety fears, 5/27.
Malaysia mixed use of early treatment with HCQ
Used early since January until about 6/22.
Reuters, https://www.reuters.com/artic..-fight-covid-19-idUSKCN21X0YQ, Exclusive: India agrees to sell hydroxychloroquine to Malaysia to help fight COVID-19, Malaysia has been using hydroxychloroquine for mild to severe COVID-19 cases along with other drugs, according to its treatment protocol seen by Reuters, 4/15.
CNA, https://www.channelnewsasia.c..till-using-treatment-12771770, Malaysia still using hydroxychloroquine to treat COVID-19 patients; health ministry monitoring side effects, did not halt based on WHO recommendation, 5/26.
CodeBlue, https://codeblue.galencentre…e-can-slow-covid-19-progress/, Malaysia Finds Hydroxychloroquine Can Slow Covid-19 Progress, 6/9.
Malay Mail, https://www.malaymail.com/new..st-wave-says-health-d/1851457, ‘Chloroquine’ used to treat Covid-19 patients since first wave, says Health D-G, 3/29.
CodeBlue, https://codeblue.galencentre…uine-from-covid-19-treatment/, Malaysia Drops Hydroxychloroquine From Covid-19 Treatment, stopped using based on study with stage 2/3 patients, not clear if stopped for early use, 6/22.
New Straits Times, https://www.nst.com.my/news/n..e-hydroxychloroquine-covid-19, Dr Noor Hisham: Malaysia drops use of hydroxychloroquine for Covid-19, 6/22.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1261701176665337857, Used since the start, 5/16.
Mexicolimited early treatment with HCQ
Mark F. McCarty, https://twitter.com/markfmccarty/status/1270421880697044993, Doctors outside hospitals not allowed to prescribe, 6/9.
El subsecretario de Prevención y Promoción, https://jalisco.quadratin.com..ara-uso-de-hidroxicloroquina/, Not authorized for COVID-19 outside of clinical trials, 5/27.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1281912523470643200, Mexico is anti-HCQ, 7/11.
Government of Mexico, https://www.gob.mx/cofepris/a..-la-poblacion-251030?idiom=es, Actualmente no existe un medicamento eficaz y seguro para la cura del paciente con Covid-19 y tampoco una vacuna para prevenirlo., still claiming no drug is effective, 8/25.
The World, https://www.pri.org/file/2020..-over-unfounded-covid-19-link, Mexico runs out of malaria drugs over unfounded COVID-19 link, 5/27.
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Morocco widespread early treatment for high-risk patients for most of the outbreak. All patients treated on first symptoms.
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
Le Nouvel Afrik, https://www.afrik.com/covid-1..nt-plus-en-europe-qu-au-maroc, Covid-19 : pourquoi les Marocains décèdent plus en Europe qu’au Maroc, All COVID patients treated with HCQ as soon as the first symptoms appear. Moroccans more likely to die in Europe than Morocco, 5/5.
The Africa Report, https://www.theafricareport.c..ne-from-dakar-to-brazzaville/, Coronavirus: Didier Raoult the African and chloroquine, from Dakar to Brazzaville, 4/15.
Afrik.com, https://www.afrik.com/edouard..ychloroquine-et-le-remdesivir, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, Follows the Raoult protocol, 7/6.
Morocco World News, https://www.moroccoworldnews…ss-reveals-european-failures/, Moroccan Scientist: Morocco’s Chloroquine Success Reveals European Failures, Zemmouri believes approximately 78% of Europe’s coronavirus-related deaths “could have been avoided” if European countries had applied the “same chloroquine strategy as Morocco.”, 6/22.
Parola et al., https://www.mediterranee-infe..2020/09/COVIDAfricaJOUMII.pdf, COVID-19 in Africa: What else?, letter regarding the large use of CQ derivatives and the relative success of countries using them, 9/11.
Al-bab, https://al-bab.com/blog/2020/..-chloroquine-despite-concerns, Covid-19: Algeria and Morocco continue using chloroquine despite concerns, 5/28.
The North Africa Post, https://northafricapost.com/4..uine-despite-controversy.html, Morocco continues use of Chloroquine despite controversy, 5/27.
Challenge, https://www.challenge.ma/coro..que-le-maroc-a-reussi-144484/, Coronavirus : ce que le Maroc a réussi, Ignored WHO recommendation, 6/13.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
Marie94167358, https://twitter.com/Marie94167358/status/1260661671816835082, Fully on HCQ since February, 5/13.
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Netherlands – limited early treatment with HCQ
De Limburger, https://www.limburger.nl/cnt/..e-behandeling-coronapatienten, Inspectie: Meijelse huisarts moet stoppen met experimentele behandeling coronapatiënten, doctors will be fined if prescribing HCQ for COVID, 4/8.
AD – Nieuws, https://www.ad.nl/binnenland/..-aan-coronapatient~a0ddaabbd/, Ziekenhuizen gaven massaal omstreden malariamedicijn aan coronapatient, used for hospitalized patients, 5/20.
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Nigeria – widespread early treatment (excluded due to young population). Reportedly everyone diagnosed is treated. Available OTC.
Nosa Imagbenikaro, https://twitter.com/nosamagbe/status/1261706460750364672, Everyone diagnosed is treated with HCQ, 5/16.
Vanguard, https://www.vanguardngr.com/2..ine-effective-as-prophylaxis/, COVID-19: Nigerian study finds Chloroquine, Hydroxychloroquine effective as Prophylaxis, 6/23.
Medical World Nigeria, https://medicalworldnigeria.c..vention-Says-NAFDAC?pid=45479, Chloroquine potent for COVID-19 prevention, says NAFDAC, The National Agency for Food and Drug Administration and Control (NAFDAC), yesterday, declared that chloroquine prevents the dreaded coronavirus. Its Director General, Prof. Christianah Mojisola Adeyeye, during an online interactive session with journalists said: “We realise that chloroquine can be used in the early stage of the COVID-19 infection as prophylactic treatment. Science does not lie.”, 8/27.
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
Pilot News, https://www.westafricanpilotn..rus-at-early-stage-nafdac-dg/, Chloroquine Can Treat Coronavirus at Early Stage – NAFDAC DG, the Director-General of the National Agency for Food and Drug Administration and Control (NAFDAC), Mojisola Adeyeye has said chloroquine is effective for the treatment of COVID-19 at the early stage of infection, 8/26.
Anadolu Agency, https://www.aa.com.tr/en/afri..quine-clinical-trials/1854814, Nigeria goes on with hydroxychloroquine clinical trial, 5/27.
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
The Guardian, https://guardian.ng/news/nige..id-19-prevention-says-nafdac/, Chloroquine potent for COVID-19 prevention, says NAFDAC, 8/26.
Nigeria News World, https://nigerianewsworld.com/..nd-mass-recovery-of-patients/, COVID-19: Jigawa govt reveals secret behind mass recovery of patients, secret behind recoveries is HCQ+AZ+Z, 5/17.
Pakistan – mixed use of early treatment with HCQ
Obtained from India, later banned.
Pakistan Armed Forces Medical Journal, https://www.pafmj.org/index.php/PAFMJ/article/view/4937, A survey regarding prohpylactic use of hydroxychloroquine/chloroquine for COVID-19 among healthcare workers of Pakistan, 8/7.
EduEngineer, https://twitter.com/EduEngineer/status/1307077916191264768, Pakistan has shipped HCQ to at least 25 countries, 9/18.
Vijay Gupta, https://twitter.com/OutOfTheD..ge/status/1314607206575218694, Pakistan is using HCQ, 10/9.
Government of Pakistan, http://covid.gov.pk/new_guide.._COVID-19_infections_1203.pdf, Clinical Management Guidelines for COVID-19 Infections, HCQ not recommended for early or late treatment, 7/2.
OpIndia, https://www.opindia.com/2020/..hloroquine-india-coronavirus/, Pakistan seeks Hydroxychloroquine from India to curb the Coronavirus pandemic, 4/15.
The News, https://www.thenews.com.pk/pr..ts-claims-top-medicine-expert, HCQ tablets proving effective in treatment of COVID-19 patients, claims top medicine expert, trials suspended but some use continues, 6/3.
ARY News, https://arynews.tv/en/corona-..-panel-dexamethasone-actemra/, Experts rule against plasma, Dexamethasone, Actemra as viable COVID-19 cures, all licenses related to stocking and selling of Hydroxychloroquine in Pakistan have been revoked and all human trials to verify its potency have been stopped, 6/22.
Panama – mixed use of early treatment with HCQ
Dropped usage at the end of May, started again in July
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1280772619034398721, Panama dropped HCQ at the end of May, 7/8.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1295618863535710208, Ban ended around Jul 22, 8/18.
Sistema Estatal de Radio y Televisión, https://sertv.gob.pa/nacionalfm/comunicado-185/, Comunicado #185, “Since the Ministry of Health authorized the use of HCQ and/or AZ as drugs to treat positive COVID-19 patients, a significant decrease in cases of this disease has been noted, said the minister”, Luis Francisco Sucre, 8/27.
PanaTimes, https://panatimes.com/proposa..oquine-again-against-covid-19, Proposal is being prepared to use hydroxychloroquine again against COVID-19, group of infectious disease doctors in the front line of battle against Covid-19 signed a proposal for HCQ+AZ for early stage patients, 7/14.
Radio Panamá, https://twitter.com/radiopanama/status/1281691420659679234, Scientific adviser to Panama’s President sees no reason to reconsider the negative stance on HCQ, 7/10.
Peru – early HCQ treatment was adopted relatively late
Some use, adopted late ~May 8. Reportedly more used in upper/middle classes. Health ministry promoted on June 8, but usage is controversial.
La Hora, https://lahora.pe/minsa-anunc..tamiento-para-casos-covid-rv/, Mina anuncia el retiro de hidroxicloroquina en tratamiento para casos covid, HCQ withdrawn, 9/9.
Ministerio de Salud, https://cdn.www.gob.pe/upload../694719/RM_270-2020-MINSA.PDF, Adopting HCQ, 5/8.
Minister of Health, https://rpp.pe/peru/actualida..ia-cientifica-noticia-1270896, Minsa sobre uso de Hidroxicloroquina e Ivermectina: No tenemos tiempo para “esperar evidencia científica”, Recommended for use, 6/4.
CNN, https://cnnespanol.cnn.com/20..mo-tratamiento-para-covid-19/, Perú da impulso a hidroxicloroquina e ivermectina como tratamiento para covid-19, Recommended for use, 6/10.
Manuelcv, https://twitter.com/manuelcl10/status/1265632450794979328, Only middle class and high class receiving proper HCQ treatment, 5/27.
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Portugal – mixed use of early treatment with HCQ
ZAP Notícias – Aeiou, https://zap.aeiou.pt/portugal..enda-hidroxicloroquina-328362, Portugal ainda não recomenda uso de hidroxicloroquina, Portugal still does not recommend the use of HCQ, 6/4.
Portual Resident, https://www.portugalresident…nd-use-of-hydroxychloroquine/, , suspended post WHO/Lancet, 5/29.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1258408833640267776, Portugal has less than half the ICU beds per capita of France or Spain and treatment at home quickly became the only option. With HCQ, the death rate was minimized, 5/7.
Qatar widespread early treatment (excluded due to young population)
Hydroxychloroquine News, https://twitter.com/niro60487..atus/1263731107578515457?s=20, Qatar health minister says they found HCQ to be highly effective, 5/22.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Used early, 5/2.
Russia widespread early treatment for high-risk patients for most of the outbreak. Approved for use April 15, they disregarded WHO’s recommendation to stop.
Russian Government, https://static-0.minzdrav.gov..%D0%A0_COVID-19_%28v.9%29.pdf, ВРЕМЕННЫЕ МЕТОДИЧЕСКИЕ РЕКОМЕНДАЦИИ ПРОФИЛАКТИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ (COVID-19), 9th edition guidelines with HCQ, 10/26.
PledgeTimes, https://pledgetimes.com/russi..or-the-treatment-of-covid-19/, Russian Ministry of Health has updated recommendations for the treatment of COVID-19, HCQ is still recommended, 10/27.
The Moscow Times, https://www.themoscowtimes.co..g-to-treat-coronavirus-a70025, Russia Approves Unproven Malaria Drug to Treat Coronavirus, 4/17.
Russian Government, http://publication.pravo.gov…t/View/0001202004160037#print, Распоряжение Правительства Российской Федерации от 16.04.2020 № 1030-р, 4/16.
The Moscow Times, https://www.themoscowtimes.co..ug-for-coronavirus-bbc-a69877, Moscow Doctors Forced to Self-Test Risky Malaria Drug for Coronavirus – BBC, 4/6.
Gummi Bear, https://twitter.com/gummibear737/status/1279874373046939649, Russian treatment protocol showing HCQ used early, 7/5.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, use not suspended post WHO/Lancet, 6/1.
The BL, https://thebl.com/world-news/..ine-drug-ccp-virus-trump.html, Russia supports the use of hydroxychloroquine, the drug to treat the CCP Virus suggested by Trump, will not follow WHO recommendation, 5/28.
Senegal widespread early treatment for high-risk patients for most of the outbreak
Used early. Prof. Raoult was born in Senegal.
NPR News, https://wfuv.org/content/sene..%80%94-and-their-contacts-too, Senegal pledges a bed for every coronavirus patient, country’s treatment plan uses HCQ despite warning from WHO, 5/17.
Teller Report, http://www.tellerreport.com/n..xychloroquine.BJeet4Kst8.html, Coronavirus: a study in Senegal confirms the effectiveness of hydroxychloroquine, 5/2.
Africanews, https://www.africanews.com/20..heal-faster-senegalese-medic/, Coronavirus patients on chloroquine heal faster – Senegalese medic, 6/4.
Belayneh, A., https://www.dovepress.com/off..eviewed-fulltext-article-RRTM, Off-Label Use of Chloroquine and Hydroxychloroquine for COVID-19 Treatment in Africa Against WHO Recommendation, 9/17.
Medical Xpress, https://medicalxpress.com/new..oroquine-virus-treatment.html, Senegal says hydroxychloroquine virus treatment is promising, 4/2.
Afrik.com, https://www.afrik.com/edouard..ychloroquine-et-le-remdesivir, Edouard Philippe emporté par le Covid, Didier Raoult, l’hydroxychloroquine et le… remdésivir, Follows the Raoult protocol, 7/6.
The Africa Report, https://www.theafricareport.c..ne-from-dakar-to-brazzaville/, Coronavirus: Didier Raoult the African and chloroquine, from Dakar to Brazzaville, 4/15.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Parola et al., https://www.mediterranee-infe..2020/09/COVIDAfricaJOUMII.pdf, COVID-19 in Africa: What else?, letter regarding the large use of CQ derivatives and the relative success of countries using them, 9/11.
Franceinfo, https://www.francetvinfo.fr/m..droxychloroquine_3983239.html, Ces pays africains qui ont décidé de continuer à soigner le Covid-19 avec l’hydroxychloroquine, continue to use after WHO warning, positive results, 5/28.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Used early, 5/2.
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South Koreawidespread early treatment (excluded due to early isolation)
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Used early, 5/2.
ChloroquineGuerilla, https://twitter.com/Prolongin..id/status/1279874993153662977, Standard of care from the beginning, 7/5.
Businessriz, https://twitter.com/businessriz/status/1261092622312955904, Promoted since January and used for prophylaxis with healthcare workers, 5/14.
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Spain – early HCQ treatment was adopted relatively late

Newsweek, https://www.newsweek.com/spai..vid-19-health-workers-1497277, Spain Launches Large-scale Study of Hydroxychloroquine and Antiretrovirals to Prevent COVID-19 in Health Workers, 4/10.
Robert McDonald, https://twitter.com/robbymcd1/status/1275152353298087936, Initially not used but started later, 6/22.
Spanish Drug Agency, https://c19study.com/files/spain1.pdf, La AEMPS informa de la distribución controlada de todo el stock de hidroxicloroquina/cloroquina, early treatment was blocked, usage was limited to chronic patients, clinical trials, and those admitted to hospital with pneumonia, 3/23.
Spanish Drug Agency, https://c19study.com/files/spain2.pdf, Fin de distribución controlada de hidroxicloroquina, end of controlled distribution of HCQ, 5/20.
Free News, https://freenews.live/spain-h..trials-of-hydroxychloroquine/, Spain has stopped most clinical trials of hydroxychloroquine, 6/23.
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Sweden limited early treatment with HCQ
Doctors instructed not to use.
Breaking News Today, https://www.breakingnewstoday..ng-used-in-swedish-hospitals/, Trump’s “Miracle Drug” Chloroquine No Longer Being Used in Swedish Hospitals, trials canceled, 4/8.
AJMC, https://www.ajmc.com/newsroom..ardiovascular-disease-covid19, Caution Strongly Recommended When Using Chloroquine, Hydroxychloroquine in Patients With Cardiovascular Disease, COVID-19, clinicians instructed not to use [H]CQ for COVID outside of trials, 4/17.
Kristoffer Stralin, https://www.medrxiv.org/conte..10.1101/2020.10.27.20220061v1, Decline in mortality among hospitalised covid-19 patients in Sweden: a nationwide observational study, HCQ use was stopped by the European Medicines Agency on April 1, 10/27.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, banned, used in the early phases of the pandemic for patients with severe symptoms, but halted in April after the European Medicines Agency recommended it only be used in clinical trials, 6/1.
Henrik Wallen, https://twitter.com/henrikwal..atus/1280439318109184000?s=21, Generally no treatment at all outside hospitals, 7/7.
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Switzerlandearly HCQ treatment was adopted relatively late
Started using May 1.
É Mo Scél, https://twitter.com/e_scel/status/1262737713725239298, Using since May 1, 5/19.
Tunisia – mixed use of early treatment with HCQ
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, banned, 6/1.
France 24, https://www.france24.com/en/e..ufacturing-hydroxychloroquine, Coronavirus pandemic: Tunisia begins manufacturing hydroxychloroquine, 4/10.
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Middle East Eye, https://www.middleeasteye.net..ne-malaria-treatment-progress, Coronavirus: Turkey says hydroxychloroquine dramatically reduces pneumonia cases, used early – “our science board suggested that the drug is really beneficial in the early stages to prevent the spread of the virus in the body”, 4/8.
BBC, https://www.bbc.com/news/world-europe-52831017, Coronavirus: How Turkey took control of Covid-19 emergency, “controversially that includes the anti-malarial drug, hydroxychloroquine, as standard”, 5/29.
David Stringer, https://twitter.com/davidstri..11/status/1264995116785246210, Everyone testing positive gets HCQ, 5/25.
The Palmer Foundation, https://www.palmerfoundation…loroquine-ministry-of-health/, Turkey: Highest COVID-19 cases and lowest fatalities in middle east, broad use hydrochloroquine – Ministry of Health, “Doctors prescribe hydroxychloroquine to everyone who is tested positive for coronavirus” Dr. Sema Turan, a member of the Turkish government’s coronavirus advisory board, 5/2.
Hydroxychloroquine News, https://twitter.com/niro60487270/status/1256675338853072896, Treating early with HCQ, 5/2.
CBS News, https://www.msn.com/en-au/new..g-touted-by-trump/ar-BB13oMXS, Turkey claims success treating virus with drug touted by Trump, 4/30.
AAPS, https://aapsonline.org/hcq-90-percent-chance/, Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients, many nations, including Turkey and India, are protecting medical workers and contacts of infected persons prophylactically, 4/28.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, continue to promote, 6/1.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1257921469914517505, Turkey has adopted early HCQ use, 5/5.
Covid19Crusher, https://twitter.com/Covid19Cr..er/status/1255516638033608710, Gradually adopted early HCQ, 4/29.
AAPS, https://www.prnewswire.com/ne..-surgeons-aaps-301098030.html, More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by the AAPS, greater access to HCQ, 7/22.
Luke Mor, https://twitter.com/LukeMor19..10/status/1271442135720615938, Turkey advocates early use, 6/12.
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Ukrainewidespread early treatment for high-risk patients for most of the outbreak. Government treatment protocol shows early use.
Ukrinform, https://www.ukrinform.net/rub..own-in-ukraine-on-june-3.html, Ukraine receives batch of hydroxychloroquine tablets from India, received additional shipment, 5/5.
Ministry of Health of Ukraine, https://www.dec.gov.ua/wp-con..20_762_protokol_covid19-f.pdf, ПРОТОКОЛ «НАДАННЯ МЕДИЧНОЇ ДОПОМОГИ ДЛЯ ЛІКУВАННЯ КОРОНАВІРУСНОЇ ХВОРОБИ (COVID-19)» , government treatment protocol showing early use, 4/2.
Ministry of Health of Ukraine, https://moz.gov.ua/uploads/5/..-dn_2106_17_09_2020_dod_1.pdf, «НАДАННЯ МЕДИЧНОЇ ДОПОМОГИ ДЛЯ ЛІКУВАННЯ КОРОНАВІРУСНОЇ ХВОРОБИ (COVID-19), 9/17.
Ministry of Health of Ukraine, https://twitter.com/MoH_Ukraine/status/1248268122332766208, Ukraine will receive an additional 320 thousand tablets with the active substance Hydroxychloroquine for symptomatic treatment of patients with #COVIDー19, 4/9.
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U.K. Government, https://www.gov.uk/government..oronavirus-covid-19-treatment, Chloroquine and Hydroxychloroquine not licensed for coronavirus (COVID-19) treatment, use is banned outside of clinical trials, 3/25.
Daily Mail, https://www.dailymail.co.uk/n..despite-doctors-using-it.html, US health regulator approves two malaria drugs as a last resort for coronavirus patients in hospital – but the UK will only let doctors use the promising medications in trials, 3/30.
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United States – limited early treatment with HCQ
FDA, https://www.fda.gov/drugs/dru..9-outside-hospital-setting-or, FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems, 4/24.
The Washington Post, https://www.washingtonpost.co..heart-issues-including-death/, FDA warns about hydroxychloroquine dangers, citing serious heart issues, including death, 4/24.
National Academy for State Health Policy, https://www.nashp.org/wp-cont..ovid-drug-chart-3-27-2020.pdf, State Rules and Recommendations Regarding Chloroquine, Hydroxychloroquine and Other Drugs Related to COVID-19, 3/27.
AAPS, https://www.prnewswire.com/ne..-surgeons-aaps-301098030.html, More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by the AAPS, pharmacists may be prevented from filling HCQ prescriptions, most Americans are unable to obtain HCQ for early treatment, and virtually no Americans are able to access it as preventive medicine, 7/22.
Texas Scorecard, https://texasscorecard.com/st..limited-coronavirus-medicine/, Physician Says Texas Pharmacy Board Limited Coronavirus Medicine, 5/12.
Harvey Risch, MD, PhD, https://www.newsweek.com/key-..tart-using-it-opinion-1519535, The Key to Defeating COVID-19 Already Exists. We Need to Start Using It, doctors have been threatened by medical boards with the chance of losing their license for prescribing HCQ, 7/23.
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Venezuelawidespread early treatment (excluded due to early isolation)
Efecto Cocuyo, https://efectococuyo.com/coro..d-19-anuncia-jorge-rodriguez/, Venezuela empieza a usar la cloroquina para tratar COVID-19, anuncia Jorge Rodríguez, used prophylactically, 3/23.
Government of Venezuela, http://www.mpps.gob.ve/index.php/sistemas/descargas, THERAPEUTIC MANAGEMENT GUIDE FOR COVID-19 PATIENTS AND CONTACTS, 10/15.
AAPS, https://www.prnewswire.com/ne..-surgeons-aaps-301098030.html, More Evidence Presented for Why Hydroxychloroquine Should be Made Available, in a New Court Filing by the AAPS, available OTC, 7/22.
Barron’s, https://www.barrons.com/news/..ividing-the-world-01591006809, Hydroxychloroquine: A Drug Dividing The World, used as preventative measure, 6/1.”
 

 
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