3/20/20, “CNN: Trump peddles unsubstantiated hope in dark times”…3/20/20, NY Times headline; ““With Minimal Evidence, Trump Asks F.D.A. to Study Malaria Drugs for Coronavirus,” nyti.ms/2JdpyHb Doctors around the world are using it. It would be crazy for the FDA *not* to “study.” Good God.” Mickey Kaus twitter... 3/19/20, "Bayer Donates 3 Million Chloroquine Tablets in Fight Against Coronavirus," Breitbart, Caplan, "At the White House’s direction, Food and Drug Administration (FDA) commissioner Stephen Hahn stated that his agency will move swiftly to put chloroquine through clinical trial testing to treat the virus."
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3/19/20, “Delingpole: Chloroquine Known as Effective Against Coronavirus Since 2005,” Breitbart, James Delingpole
“The world economy is collapsing because of the terror and mounting death toll caused by the Coronavirus pandemic. But the anti-malarial drug chloroquine is effective both as a prophylactic and treatment for the virus – and the medical establishment has known about this since at least the SARS coronavirus outbreak in 2005. What the hell is going on?
Yesterday, I reported the existence of three studies, all claiming that chloroquine phosphate had proved effective in treating the COVID-19.
This has since been confirmed by a more recent open-label non-randomised clinical trial in France by Didier Raoult M.D/Ph.D et al, completed just days ago. The sample was small but the results were convincing.
As the summary reports:
“100% of patients that received a combination of HCQ and Azithromycin tested negative and were virologically cured within 6 days of treatment.
In addition, recent guidelines from South Korea and China report that hydroxychloroquine and chloroquine are effective antiviral therapeutic treatments for novel coronavirus.”
But the story gets more extraordinary still. It turns out that the Centers for Disease Control and Prevention (CDC) has known since at least 2005 that chloroquine is effective against coronaviruses.
In 2005, Martin J Vincent et al published a study in Virology Journal titled ‘Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.’
Here are its findings:
“Background
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.”
It ought to be no surprise that chloroquine is effective against both SARS and COVID-19. After all, they are both coronaviruses and COVID-19 has often been described in medical and research sources as SARS-2.
Chloroquine works by enabling the body’s cells better to absorb zinc, which is key in preventing viral RNA transcription – and disrupting the often fatal cytokine storm.
As at least one person has noticed, the implications of this are enormous. If the medical establishment – including CDC – has been aware of the efficacy of chloroquine in treating coronavirus for at least 14 years, why has it not been mass produced and made available sooner?
“Ian Wilson@Le_Nautonnier
“Ian Wilson@Le_Nautonnier
There are grounds for everyone that has suffered and the families of those who have died for a Class Action Law suit against the CDC”
Here, you might have imagined, is the dream solution: a stop gap treatment for coronavirus which could save many lives and obviate the need for this global lockdown which is destroying our economies.
Why isn’t the solution being shouted from the rooftops?
One possibility, as I suggested yesterday, is that there is no money in it for Big Pharma. Chloroquine is a generic drug.
That’s why Big Pharma’s lobbyists have worked hard to persuade governments that there can be no acceptable solution till a patented vaccine is brought on to the market. Even if this happens it won’t be till long after the pandemic is over – probably not till at least next year.
I don’t think our businesses, our livelihoods, our sanity can wait that long. Do you?”
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Added: Thank-you, Bayer:
3/19/20, "Bayer Donates 3 Million Chloroquine Tablets in Fight Against Coronavirus," Breitbart, Joshua Caplan
"German pharmaceutical giant Bayer AG announced Thursday that it donated 3 million tablets of the malaria drug Resochin to the United States amid testimonies that it could potentially treat individuals with the deadly Chinese coronavirus.
Resochin, which is made of chloroquine phosphate, is presently not approved for consumption in the U.S., though the company is working with
federal public health agencies to secure authorization for its use
nationwide. “Resochin, a product discovered by Bayer in 1934 and indicated for prevention and treatment of malaria, also appears to have broad spectrum antiviral properties and effects on the body’s immune response. New data from initial preclinical and evolving clinical research conducted in China, while limited, shows potential for the use of Resochin in treating patients with COVID-19 infection,” Bayer said in a statement. “Bayer in recent days has been in talks with the White House, HHS, CDC, and the FDA, offering any assistance we can provide with a focus on donating Resochin to help in the government’s efforts to combat the virus.”
“Bayer thanks the Trump administration for moving quickly to enable this donation and will continue to work closely with the administration to support its efforts in the fight against COVID-19,” the statement concluded.
The announcement comes as President Donald Trump touted the use of chloroquine to treat patients who have contacted the coronavirus.
“We’re going to be able to make that drug available almost immediately,” the president told reporters at the White House press briefing on Thursday.
“The nice part is it’s been around for a long time, so we know that if things don’t go as planned, it’s not going to kill anybody,” he added.
President Trump also promoted Remdesivir, an anti-viral medication manufactured by Gilead as a potential treatment drug for the deadly illness. The anti-viral drugs have shown “very, very encouraging early results” during testing, the president said.
“I think it’s going to be very promising. It could be a game-changer,” he added “And maybe not. Based on what I see, it could be a game-changer. They’re very powerful.”
At the White House’s direction, Food and Drug Administration (FDA) commissioner Stephen Hahn stated that his agency will move swiftly to put chloroquine through clinical trial testing to treat the virus."
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